The impact is still being felt at Raleigh-Durham International Airport where nearly 20 flights are already canceled, and at least 43 flights were delayed Tuesday.
Shaq Preston is among the many Americans stuck and stranded.
He drove two hours to the airport Tuesday morning; He was in the parking garage when he received the notification his flight was canceled.
Preston said he was flying out to take an exam, and would not be rebooked until Thursday.
"So now, I got to call my school and see if I can reschedule my exam and type stuff, reschedule my hotel or rebook my hotel," he said. "Yeah, it's pretty frustrating... (I) planned for my daughter to (be in) daycare while I'm gone. So, it's a lot going on."
A family of 17 was supposed to head to Tampa Tuesday morning from RDU. Their flight was canceled 10 minutes after it was scheduled to leave.
WATCH | Headaches continue for passengers flying through Raleigh-Durham International Airport
Headaches continue for passengers flying through Raleigh-Durham International Airport
"I thought everything was great, we're the first flight out of here," James Matthew, one of 17, said. "Then, they tell us the pilot is nowhere to be found, and they don't have a captain to fly the airplane."
Costing them time and money, the family is now scrambling to find several cars to rent and drive down to Florida.
"We planned this trip months in advance," he said. "About six months now."
Since the Friday outage, Delta Airlines has canceled more than 4,000 flights. The outage affected the application used to ensure all flights have a full crew, which requires the most work.
Delta CEO Ed Bastian shared that it could be days before the airline gets back on track.
The wave of IT outages on Friday also caused disruptions in hospitals, banks and stock exchanges.
The outage partly stemmed from a software update issued by major US cybersecurity firm CrowdStrike.
RELATED | What is CrowdStrike, the company linked to the global outage?