The fire broke out at a home on Guy Road just off US 70 near Clayton around 1 a.m. Firefighters found heavy smoke coming from the home.
Garner Fire Department officials told ABC11 that they pulled a man and two dogs from the fire.
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The man later died at a hospital. One of the dogs also died.
The surviving pet is in the care of Wake County Animal Control.
Investigators are working to determine the cause of the fire.
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No other details were immediately released.
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