It was Southwest flight 1221, flying from RDU to Chicago's Midway Airport.
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After takeoff, it circled the Triangle for about 45 minutes and then landed safely at RDU about 8 p.m.
Once on the ground, the aircraft taxied to a gate under its own power.
A Southwest Airlines spokesperson told ABC11 that there were no injuries reported among the 149 passengers and six crewmembers onboard.
The FAA is investigating the incident.