The crash happened around 9 a.m. on the eastbound side of the highway.
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According to police, a vehicle merged from the Arendell Avenue on-ramp onto US 64 eastbound in front of the tractor-trailer. The driver of the truck tried to avoid the car and then lost control, hitting the guardrail and flipping onto its side.
A large amount of cabbage spilled out onto the highway.
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Three other cars were also hit and damaged by debris.
Police say charges are likely for the driver that failed to yield to the truck.