The two storied basketball programs have played hundreds of times. They're two of the best college basketball programs in history. But never before have the two met with the season on the line.
Making this year even more unique is that it represents a time of change for both programs. UNC is in the first year with its first Black head coach -- former Tar Heel player Hubert Davis. Meanwhile, Duke is in the final year of Hall of Fame coach Mike Krzyzewski's career. Duke will soon be coached by a former player of its own, Jon Scheyer.
WATCH: Duke players talk about Final Four matchup
Duke players discuss matchup against UNC in the Final Four
Duke players discuss Final Four showdown vs. UNC
But before the curtain sets on this historic season, the teams must meet one more time.
They already split the regular season, with Duke dominating North Carolina in the Dean E. Smith Center but then UNC paying Duke back in kind by denying the Blue Devils a fairytale ending for Coach K's final home game.
WATCH: UNC players speak about Final Four matchup
UNC players discuss Final Four matchup against Duke
UNC players discuss Final Four matchup against Duke
WATCH: Coaches discuss discusses the Final Four matchup
Duke coach Mike Krzyzewski discuss his last trip to the Final Four
UNC coach Hubert Davis discusses Final Four, matchup with Duke
The Blue Devils are a No. 2 seed in the tournament and the Tar Heels are a No. 8 seed and weren't expected by most observers to be here. But both teams appear to be playing their best basketball at the right time.
WATCH: Duke's 'Crazy Towel Guy' will watch this one from home
Duke's 'Crazy Towel Guy' will watch this one from home
WATCH: Durham dad shows off his UNC fan cave ahead of Final Four game against rival Duke
Durham dad shows off his UNC fan cave ahead of Final Four game against rival Duke