Police have identified the woman as 43-year-old Marcquius Timmons-Moore.
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She was found dead inside a home on York Road on Aug. 22.
The woman's death is being considered a homicide.
"She'd been dead for several days," said Capt. Samuel Oates. "We've began a nationwide search for him. We've issued warrants for his arrest for first-degree murder."
The husband, 44-year-old Michael Moore Sr. is on the run.
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Moore's 2009 Nissan Maxima was recently found in Las Vegas.
Fayetteville Police Homicide Detectives are working with Las Vegas police to help solve this case. Authorities are encouraging Michael Moore Sr. to surrender to police peacefully.
Anyone with information regarding the investigation is asked to contact Detective A. Caldwell with the Fayetteville Police Department at (910) 366-5853 or Crimestoppers at (910) 483-TIPS (8477). Crimestoppers information can also be submitted electronically, by visiting http://fay-nccrimestoppers.org and completing the anonymous online tip sheet, or by downloading the FREE "P3 Tips" app available for Apple devices in the Apple App Store and available for Android devices in Google Play.