Multiple agencies responded to US 421 South at Crawford Road.
They found one vehicle off the road by the woods. One person was pronounced dead at the scene.
ALSO SEE: Pedestrian killed in Harnett County hit-and-run crash
The victim's identity was not immediately released.
One lane of US 421 and one side of Crawford Road was closed during the investigation.
The crash was the second serious crash on US 421 at Crawford Road in the past few days. On Saturday, a head-on crash left five people hospitalized.