Elijah Brown, 17, died from his injuries, Sgt. Chris Knox of the North Carolina Highway Patrol confirmed to ABC11 on Wednesday evening.
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Brown, of Henderson, was airlifted in critical condition to Duke Hospital after Saturday's crash.
Brown was a passenger in the same vehicle as Kasi Thompson, 16, who was remembered Wednesday as part of a standing-room-only funeral in Henderson, four days after she was killed in the same crash that ultimately took Brown's life.
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Ryan Lee Matthew Taylor, 29, was charged with felony second-degree murder in Thompson's death, on top of other charges.
The Highway Patrol said Taylor failed to slow as he approached a vehicle with Thompson, Brown and another teen inside, causing the collision. They said he tried to run from the scene before he was caught by authorities.
Father of Henderson crash victim speaks at daughter's funeral