Investigators identified 27-year-old Travis Edward Jefferson as the murder suspect. He remains at-large and is considered armed and dangerous.
He faces a first-degree murder charge in the death of Nicoda Melvin on Sept. 19.
Police said Jefferson was dating Melvin and they lived together.
Three days later, on Wednesday, Sept. 22, the Cumberland County Sheriff's Office said a man walked into a home on Charlie Drive and opened fire, shooting four male victims, three of them were related to Melvin.
3 family members killed in separate shootings in less than a week
Deputies said Maurice and Marquez Melvin, Nicoda's brothers were shot; Maurice was taken to the hospital in critical condition.
Marquez and his cousin, Konye Melvin, 16, were both found dead.
Another person was also shot but is expected to be OK, deputies said.
Deputies told ABC11 that drugs were found in the home on Charlie Drive but investigators are still working to find a motive for the shooting.