Trebek, who died earlier in the month at the age of 80, was open about his stage 4 pancreatic cancer diagnosis, issuing several public service announcements and even offering words of encouragement to the late Rep. John Lewis, who faced a similar diagnosis.
Before turning to the game board for the first round of Thursday's episode, Trebek paused to share a warning about pancreatic cancer.
"If you or anyone you know has developed some of the symptoms that I have talked about in the past, then, by all means, get to a doctor, get yourself tested. I want you to be safe. This is a terrible, terrible disease," he said.
The game show will air new pre-recorded episodes hosted by Trebek until Christmas Day. Producers have not yet announced a new host.