Speaking to his "Jimmy Kimmel Live!" audience, the late-night host held back tears as he documented the birth of his son William on April 21.
"They found that Billy was born with a heart disease," Kimmel explained.
Kimmel said William was able to return home six days after open-heart surgery at Children's Hospital Los Angeles. Kimmel said William would have to undergo surgery again in three to six months.
During his monologue he thanked the nurses, doctors and staff who helped William and urged his audience to donate to Children's Hospital Los Angeles.
"Please say a prayer or send positive thoughts to the families with children who are still in the hospital now because they need it," a choked up Kimmel said.
on behalf of my family, thank you for the lovely and loving tweets about our son Billy and for your donations to https://t.co/HOIUvNt8WE XO— Jimmy Kimmel (@jimmykimmel) May 2, 2017
Kimmel revealed he would be taking the rest of the week off and guest hosts would be filling in for him. On Tuesday, Kimmel tweeted an image of his family, expressing his "sincere thanks."