Daryl Williams, who started 12 of the 16 games in which he played for the Panthers last season, has signed a one-year deal with the Bills.
Panthers linebacker Luke Kuechly, who has missed two games since suffering a concussion, is on schedule to return Sunday versus the Chargers.
The Panthers will be down to their third-string center after placing Ryan Kalil and Gino Gradkowski on injured reserve.
The Panthers must shuffle their offensive line with news that starting left tackle Michael Oher is in the concussion protocol and won't face the Falcons on Sunday.
Carolina Panthers center Ryan Kalil suffered a sprained right knee in Friday's 31-30 victory over Miami and will miss the final two preseason games, but hopes to be ready for Week 1.
Panthers offensive tackle Jonathan Martin, the player that was at the center of the Richie Incognito bullying scandal in Miami, plans to retire from the NFL, according a source.