Defending champ Novak Djokovic suffered a major upset at the hands of unseeded Denis Istomin in a marathon 4-hour, 48-minute match at the Australian Open. Istomin is ranked 117th in the world.
Serena Williams and Novak Djokovic will both face tests in the first round of the US Open as the draw was announced Friday.
Juan Martin del Potro is back, and Novak Djokovic is left reeling after a stunning singles upset at the Rio Games.
American Sam Querrey finished off his surprising upset of Novak Djokovic at Wimbledon, ending the top seed's streak of Grand Slam wins at four.
Roger Federer ended Marcus Willis' run at Wimbledon on Wednesday, while defending champion Novak Djokovic extended his winning streak to 30 matches in Grand Slam events.
Novak Djokovic's top half of the Wimbledon draw features seven-time winner Roger Federer.