Sgt. Benjamin N. Pennington, 26, was killed in Saudi Arabia.
President Donald Trump announced "major combat operations" against Iran on Feb. 28, with massive joint U.S.-Israel strikes attack targeting military and government sites, officials said.
Iranian state television confirmed that Ayatollah Ali Khamenei was among those killed in Tehran on the first day of strikes. His son Mojtaba Khamenei was chosen on Sunday to succeed him.
Iran is responding to the operation with missile and drone attacks targeting Israel, regional U.S. bases and multiple Gulf nations. Israel is also intensifying its long-running strike campaign against the Iran-backed Hezbollah militia in Lebanon.
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The U.S. has intercepted multiple Iranian missiles that were targeting U.S. bases and allies in the Middle East according to a U.S. official.
One source in the region said 14 Iranian missiles were launched toward the United Arab Emirates and were intercepted.
The source said Iran has launched missiles against Jordan, Bahrain, Kuwait, UAE and Qatar.
-ABC News' Jonathan Karl and Luis Martinez
In a brief phone call with a reporter from The Washington Post just after 4 a.m. on Saturday, President Donald Trump told the paper that all he wants is "freedom for the people" of Iran.
"All I want is freedom for the people," Trump said when asked about what he hoped his legacy would be as a result of the U.S. operation. "I want a safe nation, and that's what we're going to have."
Defense Secretary Pete Hegseth and Gen. Dan Caine, the chairman of the Joint Chiefs of Staff, are at Mar-A-Lago with President Trump monitoring today's strikes, according to a source familiar.
-ABC News' Luis Martinez
The IDF says it has identified another wave of "missiles launched from Iran toward the territory of the State of Israel. "
Sirens sounded in central Israel.
