The crash happened around 4 a.m. at the bridge near Lumley Road.
According to an accident report, 19-year-old Jack Adams of Raleigh was driving east on I-540 when he ran off the left side of the roadway.
His vehicle then went into the median, struck the cable barrier, and overturned before hitting the Lumley Road bridge abutment.
Adams was the only person in the vehicle.
Authorities said alcohol was suspected in the crash.
Two eastbound lanes of I-540 were blocked as authorities investigated. The road reopened around 7:45 a.m.