Men's March Madness 2025: Sweet 16 betting odds, lines, totals and BPI

The 2025 men's NCAA tournament began with 68 teams looking to raise a banner and write their name into college basketball history. TheAuburn Tigers, the overall No. 1 seed in the South, are looking to avenge their SEC tournament loss and claim the title as the best team in the country, but they'll face stiff competition from tournament favoritesDukeand Floridaas well as from fellow No. 1 seed Houston

The SEC made a big statement in sending 14 teams to the Big Dance with half of those making it through the first two rounds of the tournament, includingArkansas, vying for a Cinderella run as the only double-digit seed left standing.

Here are the lines, spreads and totals for the Sweet 16 round of play which will take place on Thursday and Friday.

Odds are accurate as of publication time. All times Eastern. For the latest odds, go to ESPN BET.

Thursday