Around 11:30 p.m. Friday night, officers went to an assault call at Pettigrew and South Plums Streets.
They found a man in his 20s with some kind of wound. He was taken to Duke Medical Center where he later died.
Anyone with information is asked to call Inv. D. West at (919) 560-4440, ext. 29341, or CrimeStoppers at (919) 683-1200.