To the Super Bowl winner goes the spoils of opening the entire schedule at home.
So the Los Angeles Rams will host the Buffalo Bills on Thursday night, Sept. 8, to begin the 2022 season.
It's a juicy matchup of the team generally considered the title favorite by oddsmakers in the Bills traveling to SoFi Stadium, where the Rams won the championship over Cincinnati in February.
The Bengals are home to their division rivals, the Steelers, on Sunday, Sept. 11 when all but two other teams get started. Those two clubs playing on Monday night also offer an enticing storyline: Russell Wilson bringing his Broncos to Seattle. The Seahawks traded their longtime quarterback to Denver in the offseason.
Sunday's prime-time game features Tom Brady - unless he retires again before September - and the Buccaneers at Dallas. Brady's decision to unretire after a short hiatus forced NFL schedule makers to scramble and redo some of the game slots.
The Cowboys visited the Buccaneers to open last season.
The rest of the opening Sunday has some eye-opening matches, such as Jacksonville, with new coach Doug Pederson, at Washington, with new quarterback Carson Wentz. Pederson coached Wentz in Philadelphia and won a Super Bowl with the Eagles, although Nick Foles was behind center with Wentz injured.
Several key division matchups are on tap for Sept. 11: New Orleans at Atlanta, Indianapolis at Houston, New England at Miami, Las Vegas at the Los Angeles Chargers and Green Bay at Minnesota.
"Expecting to have an unbelievable crowd there," Vikings coach Kevin O'Connell told the Vikings' website. "I've talked a lot about being on that visitor's sideline, so I know what the Packers will be in store for on opening weekend. I expect to see a stadium full of purple. It's a great opportunity for us and a challenge.
"What a way to start your season - a challenge but also a great way to kick-start what is hopefully going to be a great 2022."
Also, it will be Cleveland at Carolina, San Francisco at Chicago, Philadelphia at Detroit, Baltimore at the New York Jets, Kansas City at Arizona, and the New York Giants at Tennessee.
Teams that will open on the road and will be home in Week 2 include Kansas City hosting the Chargers in the first Amazon Prime Video game on Thursday night. Also, it will be Miami at Baltimore, the New York Jets at Cleveland, Indianapolis at Jacksonville, Tampa Bay at New Orleans, Carolina at the New York Giants, New England at Pittsburgh, Seattle at San Francisco, Houston at Denver, Arizona at Las Vegas, Chicago at Green Bay at night, Tennessee at Buffalo on Monday night, followed by Minnesota at Philadelphia.
Finally playing at home in Week 3 will be Indianapolis against Kansas City, Minnesota against Detroit, New England vs. Baltimore, and Tampa Bay vs. Green Bay, with Brady facing Aaron Rodgers.
Previously revealed was that one of the Christmas Day tripleheader games, Denver at the Rams, will be televised by Nickelodeon as well as CBS. Slime, anyone? The other Christmas games are Green Bay at Miami in the 1 p.m. slot, then Tampa Bay at Arizona at night.
Christmas Eve will also have a contest, with the Raiders at the Steelers.
The traditional Thanksgiving games will have Detroit hosting Buffalo, Dallas at home for the Giants, and New England at Minnesota at night.
More holiday fare: 14 games on New Year's Day, which will force some bowl games to adjust away from Jan. 1. The likely top matchups to begin 2023 include San Francisco at Las Vegas, Miami at New England, and Denver at Kansas City.
Also previously announced were the international games:
Week 15 has a tripleheader on Saturday, Dec. 17, though which of the five matches will be switched from Sunday won't be decided until closer to that weekend. The possibilities are Miami at Buffalo, Baltimore at Cleveland, Indianapolis at Minnesota, Atlanta at New Orleans, and the Giants at Washington.
The final weekend, Jan. 7-8, 2023 - all intra-division matchups - will also have two games moved to Saturday. Those will be determined early in Week 18.
"For months, we've known who we're playing and where," Browns coach Kevin Stefanski said, "but to see how it unfolds, where our bye week is and where our division opponents are is fun for our coaches. That first opponent is something you look at so you can start to work on their coordinators, understand what they've done and try and get a head start on that game."
Only one franchise is not set for prime time: Detroit. But the league's flex schedule could change that if the Lions show significant improvement.
In contrast, the Rams, Packers, Bucs, Broncos, Eagles, Cowboys, Chargers, Chiefs, Steelers, 49ers, Patriots and Bengals each have five night games.
Oddly, the AFC champion Bengals face all three division foes (Cleveland, Baltimore and Pittsburgh) on the road in prime time. Las Vegas has three straight night games in December.
Nine teams will enjoy three-game homestands: the Cowboys, Giants, Bears, Lions, Vikings, Panthers, Buccaneers, Rams and 49ers. Four must endure three-game road trips: Kansas City, Miami, Green Bay and Philadelphia.
Byes begin in Week 6.
Two notable anniversaries:
Fox will not televise World Cup matches from Qatar on Nov. 27 and Dec. 4 in favor of NFL games. The World Cup final at 10 a.m. EST on Dec. 18 will be followed on Fox at 1 p.m. by split coverage of Lions-Jets and Cowboys-Jaguars, and at 4:05 p.m. by Cardinals-Broncos.
The Carolina Panthers open the season at home on Sept. 11 against the Browns. Four of the Panthers' first five games are in Charlotte.
The Panthers aren't getting a lot of prime-time love this season, as the NFL expects them to be among the league's worst teams, but there is one prime-time game, a Thursday night (Nov. 10) home game against the Atlanta Falcons. That game will be shown on Amazon's Prime Video.
Carolina will have home games in weeks 3-5, hosting the Saints, the Cardinals and the 49ers, respectively. The Panthers will follow up that stretch with a visit to the Rams.
The team's final home game will be on Christmas Eve against the Detroit Lions. Kickoff is set for 1 p.m.
The Panthers will close out the regular season with a trip to division rival New Orleans on Jan. 1, a Monday. The time hasn't been determined.
The ESPN/ABC games have already been announced. The Carolina Panthers don't appear in any of them.
Week 2 will feature a Monday Night Doubleheader on Sept.19 with the Tennessee Titans at the Buffalo Bills at 7:15 p.m. on ESPN followed by the Minnesota Vikings at the Philadelphia Eagles on ABC set for 8:30 p.m.
Week 3 of Monday Night Football (Sept. 26) has an NFC East matchup with the Dallas Cowboys visiting the New York Giants (8:15 p.m. on ESPN)
Other notable matchups include the Las Vegas Raiders at the Chiefs in Week 5 (Oct. 10 at 8:15 p.m.on ESPN), a game in London between the Denver Broncos and Jacksonville Jaguars on Oct. 30 beginning at 9:30 a.m. on ESPN+, and a Week 11 matchup in Mexico City between the San Francisco 49ers and the Arizona Cardinals on Nov. 21 at 8:15 p.m. on ESPN.
A Dec. 19 showdown in Week 15 showcases the defending Super Bowl champion Los Angeles Rams at the Green Bay Packers (8:15 p.m., ESPN).
There's an appealing matchup in Week 17 on Jan. 2's Monday Night Football, with the Bills visiting the Super Bowl runner-up Cincinnati Bengals (8:15 p.m., ESPN)
The ESPN/ABC slate wraps up with a Week 18 Saturday Night doubleheader on Jan. 7. Games are TBA.