Agents said they seized five firearms, cocaine, meth, liquor and cash.
Federal authorities on Thursday announced indictments against 20 people, including 14 current or former Mississippi Delta law enforcement officers.
Four people were arrested, with charges pending against a fifth, totaling 41 charges, including 21 felonies and 20 misdemeanors.
ALE said they launched an investigation into criminal activity involving illegal drugs being sold in convenience store parking lots.
The Durham County Sheriff's Office said a large amount of money, a firearm, and drug paraphernalia were also seized from the car.
A Raleigh firefighter and his wife face at least 10 years in prison.