When firefighters arrived, the 2-story apartment was already engulfed in flames.
Officials say the mother, 36-year-old Yolanda Denise Gipson, was pronounced dead at the scene and her two children, 13-year-old Deja Gipson and 2-year-old Destiny Gipson, died later at a hospital.
According to police, the woman's 18-year-old son escaped the blaze unharmed and called 911.
Officials say the fire began in the kitchen due to food that was left unattended cooking on the stove.