Durham police attempted to stop a 1996 Chevrolet pick-up truck for a traffic violation on Guess Road in Durham around 12:45 p.m.
Police say the driver pulled into the parking lot of the Hog Heaven Restaurant on Guess Road, but sped away as police approached his truck.
The driver of the truck, 20-year-old Christopher Cyr, turned onto the entrance ramp to Interstate 85 South and struck a Toyota Camry on the ramp.
An occupant of the Camry was treated for minor injuries.
Cyr was not being chased by police when the accident happened. However, he kept going on I-85 South and exited on Hillandale Road.
He ran a red light at Hillandale Road and collided with a northbound 1999 Dodge work van. The van collided with a northbound 2001 Toyota Tacoma in the next lane and then rolled across the median and over the hood of a southbound Durham police car.
Police say Cyr's truck came to a stop in the northbound lanes of Hillandale Road.
He suffered head injuries and was taken to Duke University Hospital for treatment. His condition is not known at this time. Authorities say the driver of the Tacoma was also taken to Duke. The other people involved were treated for minor injuries. None of the injuries appear to be life-threatening.
Cyr is facing charges of felony hit-and-run, felony fleeing to elude officers, careless and reckless driving, running a red light, driving without a license and possession of drug paraphernalia.
The Dodge van and the 1996 Chevrolet pickup truck sustained heavy damage, while the 2009 Ford Crown Victoria patrol car sustained approximately $3,000 damage.
Hillandale Road was shut down for more than two hours as crews cleared the scene.