It happened Monday along the Stone Creek Greenway between Davis Drive and Carpenter Upchurch Road.
The first bite victim was a jogger.
"He was able to kick it off and then it came back for more, and then the victim, or the gentleman was bit and he ended up starting the rabies treatment at Apex hospital," explained Shelly Davis with Cary Animal Control.
Hours later, a 5-year-old boy was attacked while playing in his backyard.
"The little boy was bit in his backyard, which his backyard backs up to the greenway," Davis explained. "He was bit at least twice, if not three times."
Davis says the town closed the greenway down and set two traps, but cannot find the suspected rabid fox.
"I'm assuming that the fox died from the rabies virus because once they start showing the symptoms, and it hits the neurological systems, they die soon afterwards," said Davis.
The greenway reopened Thursday. Davis says Animal Control has been inundated with calls of fox sightings, but they can't respond to every one.
"I had one lady chew me out yesterday, I mean, she chewed me out, because I wouldn't catch the three foxes that were in her backyard, and I need people to understand that we're not out to catch every fox that people see, only the ones that are sick or injured," said Davis.