Investigators said it happened at a vacant house on Grace Lane.
"It was like 'Pop, pop, pop.' A lot of them going off, said Davina Dunston.
Dunston described the chaos after the gunfire less than 500 feet away from her house where her two-month-old nephew was sleeping.
The gunshots echoed through east Durham around 1:30 p.m. Tuesday.
No fewer than 10 Durham police cruisers crowded the intersection of Liberty and Elizabeth Streets.
Two boys, ages 14 and 16, were critically injured according to police.
One of the boys who was shot walked wounded down the block and flagged down a Durham County senior citizen transit bus and pleaded for help from the driver.
"He said. 'Help me! I got shot," said Minnie McNeil, who was on that bus.
The teenage victims were rushed to the hospital. The shooter got away.
As day turned to night, Durham crime scene investigators searched for clues at the home where the gunfire began.
Police canvassed the area all evening long but there are still no arrests.
One woman who lives nearby told ABC11 that she saw a gold or beige Jeep speeding away from the scene in the seconds after the gunfire.
Anyone with information about the shooting should contact police.