The two-vehicle wreck happened just before 5:30 p.m. A man and a woman in one car and an adult and three children in the other vehicle were all taken to the hospital.
Police did not release the conditions of the injured people.
S. New Hope Road is temporarily closed between Global Street and Durach Road as the investigation continues.
Motorists are advised to avoid the area.
An ABC11 crew is on its way to the scene. Check back for updates.
See breaking news? Tell us about it here.