State troopers said an 18-wheeler rear-ended an SUV waiting at a red light, starting the deadly chain of events.
RDU saw more than a 100 delays and double-digit cancellations as of Friday night.
This comes after the Chris Brown concert at Carter Finley Stadium exposed traffic problems during big events in that part of Raleigh.
Fans and social media users cast their blame at different agencies for the frustrating arrival and departure experience.
Enbridge Gas said a gas line was damaged in the 4000 block of North Roxboro Street, causing the closure.
The bus carrying 20 students from Union Pines High School ended up in a ditch.