Eyewitness News has learned a man in his 50s to 60s was home alone at the time.
Officials say they found the man on the floor about five feet away from the front door. They believe the blaze started in a room in the middle of the home.
Firefighters haven't identified the resident who was burned or how the fire started.
Commander Eric Tipton with Fayetteville Fire Department says the man was sent to Cape Fear Valley Hospital, then life-flighted to UNC Hospitals in critical condition.
Firefighters quickly put out the fire, but not before it gutted one end of the home.
Neighbors say the man who was burned, had just recently moved in with his sister.
Neighbors say they saw flames shooting out of one end of the home and called 911, fearing the worst.
"I knew he was in there and I was thinking that I was just hoping that they could get here and get him out," neighbor Earline Coston said. "I felt like he was in that house and sure enough he was in there, and I saw them dragging him out, I knew they had him and I was happy they had him out."
Firefighters are investigating the cause of the blaze.