It happened at the intersection of Old Smithfield Road and Highway 55 in Holly Springs around 7:20 a.m.
Holly Springs police said a white GMC Envoy made a left turn from Old Smithfield onto Highway 55 in the path of the bus. The bus hit the SUV on the driver's side.
There were 14 students on board. Two were taken to WakeMed as a precaution, but they were later released. The bus driver also went to the hospital with a leg injury.
The driver of the SUV was also hospitalized with leg, shoulder and neck injuries.
A second bus collected the remaining students and took them on to Lufkin Road Middle School in Apex.
The investigation into the cause of the wreck remains under investigation.