The SPCA took custody of 14 dogs Thursday and took them to their intake center in Garner.
The dogs were part of a breeding operation in Danbury, which is just north of Winston-Salem. Authorities said conditions at the alleged puppy mill were deplorable.
The dogs will be continuously monitored as part of the investigation.
"They need to have their nails trimmed, given baths and just learn what a human touch feels like," said Darci VanderSlik, with the Wake County SPCA, "and that it's not all bad and that good things are to come for here on out."
In all, more than 150 dogs were rescued in the raid. Most of them were French bulldogs and Chihuahuas.