It happened around 3:30 a.m. in the 4400 block of Waterbury Road.
Police said when they arrived at the home, they found 26-year-old Daniel Lavon Norris shot. He later died at WakeMed.
Based on the preliminary investigation, police said the incident does not appear to have been a random act.
Anyone with information that might assist detectives is asked to call Raleigh CrimeStoppers at (919) 834-HELP. CrimeStoppers pays cash rewards for anonymous tips that help solve cases.