It happened around 5 a.m. near mile marker 166, about 7 miles south of Roanoke Rapids.
Authorities said the tractor-trailer ran off the interstate and crashed in a nearby wooded area.
The accident caused one northbound lane to be shutdown as crews worked to clear the scene.
It was unclear what caused the truck to run off the road. The name of the person killed in the crash has not been released.
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