It happened in Classroom 202 in the West Duke Building, which is located at the corner of West Main Street and Broad Street.
Officials said a drop down acoustical ceiling collapsed and some of the original plaster ceiling also fell.
The building, which contains classroom and office space, is now evacuated until further notice and is closed. Classes in the building will be rescheduled or relocated until the building reopens.
An instructor and students were in the room and heard sounds around the ceiling tile and left the room before the ceiling fell.