Shelly Pannell, 25, was reported missing by her family shortly after 3 p.m. Sunday. Police said there were signs of a break-in at the home. Pannell is a black female, 5 feet 7 inches tall.
Police believe she may be with Earnest Lee Bryant, 25. He is reported to be driving a 2005 turquoise Toyota Highlander with the North Carolina license plate SXT 6693.
Holly Springs police said Bryant has an arrest record and has been known to carry a firearm.
Anyone with information should contact Holly Springs police at (919) 557-9111.