In the first incident, police say shots were fired around 9:45 p.m. Tuesday in the parking lot of the Red Lobster restaurant located on Durham-Chapel Hill Boulevard.
Police found 52-year-old Larry Donnell of East Pointe, Ga. with gunshot wounds. He was taken to Duke University where he died.
A short time later, officers found 30-year-old Robert Terry of Durham shot. He was sitting inside a parked vehicle outside the AMF bowling alley located on Durham-Chapel Hill Blvd. He was taken to the hospital with a non-life-threatening wound to his arm.
Police have not said if the incidents are related and no charges have been filed in either incident.
And in a third incident that happened around 1:30 a.m. Wednesday, authorities responded to a shooting on Ruby Ridge Road in Durham County. They found one victim at the scene -- a 16-year-old boy, who had been shot in the head.
The victim was riding in a car with friends when someone opened fire on the car.
The 18-year-old driver, who does not want to be identified, told ABC11 Eyewitness News he and his friends were on their way to grab a bite to eat after leaving a party. They noticed an unfamiliar car following them, so they pulled into an Exxon gas station near I-85 and Club Boulevard.
"I heard one shot," the driver recalled. "The first shot was 'Wow, what was that?' He was like, 'I don't know, I don't know.' And then I heard multiple shots after that, like 'pow, pow, pow.' So I hit the gas!"
He says all he saw was blood everywhere.
After pulling off, he realized at least one of the passengers in his car was shot. One of the gunshots hit his rear window, wounding the 16-year-old, who was in the back seat.
"And I looked back and my boy was bleeding," he said. "I panicked, I was like we need to get the hospital, we need to get to the hospital. I didn't know what to do!"
He says the wounded teen's mother told him to drive to Ruby Ridge Road and she called for an ambulance.
On Thursday, authorities said the teen died at the hospital as a result of his injuries.
All of the incidents remain under investigation and no suspect information has been released.
Anyone with information about the Durham-Chapel Hill Blvd. shootings can call Investigator Sole at 560-4440, ext. 29350 or CrimeStoppers at 683-1200.
The Durham County Sheriff's Office says it is seeking information from anyone who knows about "a disturbance" at the Cook-Out restaurant on Hillsborough Road that happened early Wednesday morning. The information may provide clues about the Exxon shooting. If you have a tip, call Detective Gaines at (919) 560-0880.