They say two armed men wearing dark colored ski masks entered the bank on 10702 US Hwy 70W Business just after 9:30 a.m.
No one was hurt, but the suspects got away.
The men were last seen running toward a wooded area on the east side of the bank.
Police said it's likely the robbers escaped in a vehicle parked or waiting nearby. They're looking for a burgundy 2001 Oldsmobile Aurora seen leaving the area of the bank and would like to question the driver/occupants of the vehicle.
Anyone with information is asked to call the Clayton Police Department at (919) 553-4611. They can also call the Clayton Crime Stoppers tip line at (919) 359-TIPZ (8479).
All information obtained from the tip-line will remain confidential and callers will not be identified. A Crime Stoppers cash reward of up to $2,500 is available if information is provided that leads to arrest(s).