Police are calling the mother of two's disappearance suspicious, because she has no prior history of disappearing and has a close relationship with her kids.
Ackerson's brother told ABC11 Tuesday that he's very concerned.
"I hope that she comes back safely and, you know, just want to have a quick ending to this," said Jason Ackerman. "She tries to see them as often as possible. Something's happened to her, I think."
Ackerson is described as a white woman with long brown hair and brown eyes. She was last seen inside her 2006 white 4-door Ford Focus with the North Carolina license tag number ZTL-7433. Police said the car was located near 5400 Summit Manor Lane in Raleigh Wednesday morning.
Raleigh Police Department spokesperson Jim Sughrue said detectives have not uncovered any evidence showing foul play is involved in Ackerson's disappearance.
Anyone with information is asked to contact the Raleigh CrimeStoppers tip line at (919) 834-HELP.