The suspects were seen in surveillance video driving the bus from the daycare on Sandhill Road in Hope Mills.
The pair is described as white males, wearing jeans and T-shirts. One of the men was also wearing a dark colored ski mask and the other had on a baseball cap and was carrying a black bag.
Detectives are currently looking for the bus. The vehicle is a white 1988 model bus and has red lettering on the side.
Anyone with information is urged to contact the Cumberland County Sheriff's Office at (910) 323-1500.