It happened just before 3 a.m. in the 200 block of Cecil Street near Chautauqua Avenue.
Authorities said 33-year-old Kinta Lamont Newman was shot by an unidentified suspect. Newman was taken to a nearby hospital by acquaintances, where he later died.
Investigators are currently searching for the suspect who was described as an African American man driving a dark-colored Cadillac. He was last seen wearing a white-colored turtle neck shirt.
Anyone with information about the incident is asked to call Investigator C. Sole at (919) 560-4440 ext. 29350 or Crime Stoppers at (919) 683-1200.