That collision ignited a fire that closed all eastbound lanes of Interstate 40 near Airport Boulevard in Wake County.
Chopper 11 flew over the scene and saw at least four vehicles crashed on the farthest left lane. Firefighters were on the scene and extinguished the fire.
The Highway Patrol confirmed at least one person died in the crash.
The identity of the person killed has not been released.
The North Carolina Department of Transportation said the crash happened around 1:30 p.m.
The lanes reopened just before 6:30 p.m.
The Highway Patrol is investigating.