The crash is located between the exits for Highway 264 and Poole Road.
Raleigh Police Department said it received a call about the crash at around 4:30 a.m. When officers arrived, they found the drivers of each vehicle suffering from serious injuries.
Both drivers were taken to the hospital for treatment.
The road remains shut down and is not expected to reopen until at least 8 a.m. Traffic is being diverted onto Highway 87.
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