Trump took the stage shortly before 7 p.m. at the Greensboro Coliseum on Tuesday night, the same day as his 70th birthday. He spoke for nearly an hour.
WATCH: Protesters march and police subdue one demonstrator outside the Greensboro Coliseum
He opened his speech by introducing a North Carolina icon, NASCAR legend Richard Petty, a longtime supporter of Republican politics.
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"If you don't discuss the problem and can't say the real name, we have a radical Islamic terrorist problem, folks," Trump told the crowd, taking aim squarely at President Obama.
The event comes a day after he delivered a speech in New Hampshire on national security and immigration in light of last weekend's mass shooting at a nightclub in Orlando, Florida, that left 50 people dead. Trump vowed if elected to impose a broad ban on immigration from areas of the world with a history of terrorism.
Two protesters ejected with crowd chanting "USA, USA.." after Trump offers signature: "Get 'em outta here." #ABC11— Jon Camp (@JonCampABC11) June 14, 2016
The executive director of the state Republican Party said he expected Trump's speech to be heavy on foreign policy and touch on the Orlando mass shooting.
WATCH: NC GOP's Dallas Woodhouse on why Donald Trump is the right man for the White House
"Radical Islam discriminates against no one, black or white, gay or straight, man or woman," said Dallas Woodhouse, executive director of the NC GOP. "And we've got to have someone in the White House that understands that and can lead us to safety and protecting Americans, and I think Mr. Trump is the right guy to do that."
WATCH: Attendees react as Donald Trump takes the stage
Trump last made an appearance in North Carolina on March 14 - the day before the North Carolina primary that he won over Ted Cruz and others.
About 6,000 people were expected to be in the arena to hear Trump speak.
The Associated Press contributed to this report.
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