Vaughn Telemaque picked off two passes, and defensive tackle Micanor Regis returned an interception 22 yards for a touchdown for Miami, which intercepted five passes and forced two fumbles.
Sean Renfree was picked off five times and fumbled a snap for Duke (1-5, 0-3). The Blue Devils lost their fifth straight.
Damien Berry rushed for 111 yards, and his 1-yard score in the third put the Hurricanes up 28-10.
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