All lanes were closed near mile marker 168, causing motorists to bypass the accident using the shoulder of the interstate.
Officials said it happened shortly after 2 p.m. when a Jeep overturned and hit the guardrail.
The second wreck involved a semi-truck and a mini-van.
The ten people taken to the hospital were said to have minor injuries.
By 4 p.m., the lanes were opened to slow moving traffic.