Police said three suspects entered the store on North Roxboro Street, flashed a weapon, and were able to make it out of the store with the cash register.
Two of the three suspects were later apprehended on West Delafield Street. Police have not released their names or the name of the third suspect.
The robbery comes just one day after a man was robbed in the store's parking lot. On Thursday, a suspect pulled a knife on the victim and stole items from his car. Police were able to arrest 25-year-old Marquis Watson in connection with the robbery.
Anyone with information is encouraged to call Durham Crimestoppers at (919) 683-1200.