A little after 8:30 p.m. on Friday, the Durham Police Department reported that the shooting happened in the area of Elm Street and Dale Street.
A man was taken to the hospital with critical injuries.
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Overnight, officers responded to a shooting in the area of Angier Avenue and Alston Avenue.
A man was taken to the hospital with life-threatening injuries.
Durham police have not said if the two shootings are connected.
An investigation is underway.
This marks the third shooting in Durham since Friday night.