The collision was reported shortly before 11 p.m. on the northbound 5 Freeway, just south of Alicia Parkway, according to the Orange County Fire Authority.
Among the injured was a woman in her 20s and three men in their 40s and 50s, fire officials said. One of the patients was in critical condition, while the other three suffered minor injuries.
Ferrell was seen on a gurney, apparently speaking on a cellphone, before firefighter-paramedics placed him into an ambulance at the scene.
The California Highway Patrol said Ferrell was transported to Mission Hospital. He has since been released.
The cause of the crash was under investigation by the CHP, who said alcohol and drugs do not seem to be a factor in the incident.
Thoughts and love out to Will Ferrell and his friends and family today. Quick healing. Godspeed.— jason alexander (@IJasonAlexander) April 13, 2018
DEVELOPING: More details will be added to this report as they become available.