It happened right after 5:30 a.m. on the Durham Freeway between Ellis Road and Glover Road.
Police said Jon Ryan Latham, 44, of Cary, was in the lane of the northbound freeway when he was struck by multiple vehicles. Latham was pronounced dead at the scene.
Northbound traffic was shut down for more than five hours. The road reopened around 1 p.m.
Investigators are looking for a late model silver or gray Dodge Grand Caravan with pieces missing from the bumper.
Anyone who may have information on this crash can contact Investigator Henry at (919) 560-4935, ext. 29449 or CrimeStoppers at (919) 683-1200. CrimeStoppers pays cash rewards for information leading to arrests in felony cases and callers never have to identify themselves.