Noel, who made his season debut Sunday after recovering from offseason knee surgery only to sprain his left ankle and miss Wednesday's game, had two points in eight minutes against the Lakers. Afterward, he aired his frustration.
"I think I'm too good to be playing eight minutes," said Noel, the No. 6 pick in the 2013 draft. "That's crazy. Need to figure this s--- out."
Noel missed the first 23 games of the season after undergoing surgery on his left knee in late October. He scored eight points in 10 minutes in his much-anticipated season debut Sunday against the Detroit Pistons but left the game in the first half with a left ankle sprain and did not return.
Friday's game marked the first time the Sixers had all three of their coveted big men -- Noel, Joel Embiid and Jahlil Okafor -- available together at the same time.
Okafor, picked third in the 2015 draft, started alongside Embiid for the second time. He had 14 points.
The duo also started in Wednesday's 123-114 loss to the Raptors, and Embiid, the No. 3 pick in 2014, had his worst game as a pro, tallying a season-low nine points.
Embiid and Okafor didn't look very comfortable together on the floor again. Both natural centers, Embiid moved to the power forward spot to accommodate Okafor.
"Never from the start to the finish did you feel like you were in any type of rhythm or flow," 76ers coach Brett Brown said. "It doesn't surprise me. It saddens me, but it doesn't surprise me."
The Associated Press contributed to this report.