A woman was also arrested in Raleigh, accused of helping the shooting suspect flee the state.
No arrests have been made.
The 9-year anniversary of the Pulse nightclub massacre comes as Orlando moves forward with plans to raze the building and build a memorial honoring the 49 victims.
The charges follow an investigation into a drug deal inside the nightclub Insomnia on Fenton Street.
It happened Friday morning near UNC-Greensboro campus at the Culture Lounge.
The cause of the blaze is not yet known as rescuers continue to search for more victims.