Police say one man is dead, two men are in serious condition and two others are reportedly in stable condition at Cape Fear Valley Medical Center.
The names of the victims are not being released at this time.
Detectives say they have yet to determine what happened at the home where the men were shot.
Homicide detectives are currently investigating.
Anyone with information regarding the incident is urged to contact the Cumberland County Sheriff's Office at (910) 323-1500 or call the Fayetteville Police Department.