It happened on Hope Mills Road in front of a Sonic restaurant and Advance Auto Parts store near George Owen and Camden roads.
Pictures from Chopper 11 HD showed a black Ford Mustang and a white Toyota mini-van with extreme front end damage. A furniture truck was also involved.
Late Thursday evening, police confirmed that the driver of the Mustang, 26-year-old Tristan Hanna from Webster, New York, the driver of the mini-van, 26-year-old Hien Troung from Parkton, and Troung's 8-month-old daughter all died at UNC Hospitals.
Troung's wife was also inside the mini-van, while Hanna's fiancee was a passenger in the Mustang.
Hanna, Troung and his daughter were all life-flighted from the scene to Chapel Hill, where they later died.
"We had three patients pinned in; all of them were code traumas," Hope Mills Fire Chief Chief Chuck Hodges said.
Troung's wife and Hanna's fiancee were sent to Cape Fear Valley Medical Center in critical condition.
Hope Mills police have not released the names of the women.
Eyewitnesses at the scene say they saw the Mustang traveling at a high rate of speed before the crash.
"He was in the middle lane doing about 90 when he swerved into the oncoming traffic side to miss a car and he hit a white van," Eyewitness Travis Carson said.
Witnesses say the car slammed into the mini-van causing the van to spin around and hit the furniture truck.
Two people inside the panel truck were not hurt.
"There was a little baby, she was really bad she wasn't breathing when they took her," truck passenger Charles Speas said.
All four lanes of Hope Mills Road had to blocked off as crews cleared the scene.
Police say the Mustang was packed with luggage, clothes and household items including numerous liquor bottles, but at this point police don't believe alcohol was a factor in the accident, however, officers say speed certainly was.
They say Hanna was a contract nurse at Cape Fear Valley Medical Center. His job had just run out, so he packed up his personal belonging and was on his way back home to New York.